I think you'd be the first. The F hasn't been around long enough to know those answers. There has to be a "First" so..... 8)
It will fit the rim, but the inner fender rail is what hits on the C so it isn't that big a deal to cut that.
I put the 200-50x18 on our VTX1800C and the tire rubbed the right side of the fender cage and even after cutting it we still had some rubbing on one of the bolts. The tire is off of the bike now and we are back to the 180-50x18.
The 200 -50x18 has a very pronounced joint where the tread and sidewall meet. That is what hits.